CARsgen, a biopharmaceutical company specializing in the development of innovative cellular immunotherapies for cancer treatment, has entered into a collaboration with Moderna, a pioneer in the field of messenger RNA (mRNA) therapeutics and vaccines. The two companies will work together to test the efficacy of CARsgen’s Claudin18.2 CAR T-cell candidate, CT041, in combination with Moderna’s investigational mRNA cancer vaccine.
The collaboration will encompass preclinical and Phase I studies that aim to explore the potential synergies between the two candidates. Moderna’s mRNA cancer vaccine is specifically designed to target the Claudin18.2 protein, which is also the main focus of CARsgen’s CT041. By combining the unique mechanisms of action offered by CAR T-cell therapy and mRNA vaccine technology, the companies hope to enhance the ability to combat cancer cells.
CT041, CARsgen’s Claudin18.2 CAR T-cell candidate, is already being evaluated in clinical trials for gastric, pancreatic, and other digestive system cancers in China and North America. The candidate has shown promise in early studies and is considered the “most advanced” solid tumor CAR-T therapy currently in development. It has received orphan drug designation from the US Food and Drug Administration (FDA) in 2020, granting it valuable incentives and exclusivity rights, and regenerative medicine advanced therapy designation in 2022, further highlighting its potential as an innovative treatment option.
The collaboration between CARsgen and Moderna represents a significant step forward in the fight against cancer. By combining their expertise and resources, the two companies aim to push the boundaries of cancer therapy and unlock new treatment possibilities. If successful, this partnership could potentially revolutionize the field of cancer immunotherapy and provide hope for patients facing hard-to-treat solid tumors.
Dr. Zonghai Li, CEO of CARsgen, expressed his excitement about the collaboration, stating, “We are thrilled to work with Moderna to explore the potential synergies between CT041 and their mRNA cancer vaccine. By combining our strengths, we aim to accelerate the development of effective and personalized cancer treatments.”
The collaboration between CARsgen and Moderna highlights the importance of partnerships and collaboration within the biopharmaceutical industry. By leveraging each other’s strengths and resources, companies can accelerate the development of innovative therapies and improve patient outcomes. As the research and development of CT041 and Moderna’s mRNA cancer vaccine progress, the medical community eagerly awaits the results of their joint efforts and the potential impact on cancer patients worldwide.
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